Author(s)

Wenxin Jiang, Yihan Wang, Tian Yang Zhou

Corresponding Author

Wenxin Jiang

ABSTRACT

The COVID-19 pandemic and the severe acute respiratory syndrome coronavirus 2 virus present important diagnostic challenges. Serology tests detect SARS-CoV-2 infection and use to confirm the presence of current infection. Serological tests can be categorized into lab-based and cassette-based assays. Generally, while lab-based assays are more sensitive and specific, cassette-based assays can be more easily handled and produced at much lower costs, rendering the two types of serological tests with distinct applications during the pandemic. Serology of the novel COVID-19 virus is still an under-researched area. The development of serologic tests requires comprehension of several aspects, including the structural basis of the virus and the mechanism of antibody tests. These tests results will provide scientific instruction to design; evaluate vaccines and therapeutic antibodies in the future. CCS CONCEPTS• Applied computing • Life and medical sciences • Health care information systems.

KEYWORDS

COVID-19, diagnostic tests, antibodies, immunology, coronavirus