Author(s)

Yuzhong Gu, Xianzhe Que

Corresponding Author

Yuzhong Gu

ABSTRACT

G-protein coupled receptor (GPCR) is a big family of protein which serves as signal receptors in the surface of cells, induces various cell responses and is widely used in drug discovery. On the other hand, Alzheimer’s disease (AD) is a kind of popular brain disease which causes memory loss, behavior changes and cognitive deficits. However, the connection between GPCR and AD, especially how can GPCR be used to treat AD has not been discussed thoroughly. Therefore, in this review, we introduce basic knowledge of GPCR and its perspective related to drugs. Besides, we conclude history, causes and symptoms of AD. In addition, several examples of GPCR pathways involved in AD treatment are fully discussed to explain connection between GPCR and AD. To summarize, this review provides detailed information about GPCR, AD and their connection, which shows bright future for drug invention via GPCR in AD.

KEYWORDS

GPCR, Alzheimer’s disease, Drug discovery