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Exploration on the Mechanism of Action of Huangqin and Gegen in the Treatment of Non-Alcoholic Fatty Liver Disease Based on Network Pharmacology

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DOI: 10.23977/medbm.2024.020109 | Downloads: 8 | Views: 167

Author(s)

Zhou Changjing 1, Lu Bo 2

Affiliation(s)

1 Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China
2 Shaanxi Provincial Hospital of Chinese Medicine, Xi'an, Shaanxi, 710003, China

Corresponding Author

Lu Bo

ABSTRACT

In order to investigate the mechanism of action of Scutellaria baicalensis-gem root medicines in the treatment of non-alcoholic fatty liver disease (NAFLD) using a network pharmacology approach. We used the TCM Systematic Pharmacology Database and Analysis Platform (TCMSP) and Uniprot database to screen the active ingredients and targets of Scutellaria baicalensis and Pueraria lobata. The GeneCard and OMIM databases were accessed to search for disease-related targets; the anti-NASH targets of GGQLT were obtained by using the Wayne Diagram online software; the egg-autoplasmic-egg-autoplasmic interaction (EAEI) network was created by using Cytoscape 3.7.2; and the Metascape online software was used to perform the gene ontology (GO) enrichment and Kyoto Gene and Genome Encyclopedia of Genes and Genomes (KEGG) signaling pathway analysis. Resultly, we obtained 19 components of Scutellaria baicalensis and Pueraria lobata with 540 targets. 3,610 NASH targets and 57 Scutellaria baicalensis-kudzu drug-antagonistic NAFLD sites were obtained. Visualization analysis showed that the top 3 scutellaria baicalensis-kudzu drug against NAFLD targets were estrogen receptor 1 (ESR1), B lymphoblastoma-2 gene (BCL2), and mitogen-activated protein kinase 8 (MAPK8). 179 entries were obtained by GO enrichment analysis, and 145 signaling pathways were obtained by KEGG signaling pathway analysis. In conclusion, in this study, we obtained the chemical constituents and targets of Scutellaria baicalensis-Geranium medicinal pairs through network pharmacology, screened the key constituents and key targets of Scutellaria baicalensis-Geranium against NAFLD, and analyzed the mechanism of action of Scutellaria baicalensis-Geranium medicinal pairs against pitted NAFLD, in order to provide an opportunity for Scutellaria baicalensis- Pueraria Mirifica drug on the treatment of NASHFLD to provide more theories and bases, and at the same time to provide a certain theoretical basis for further research on Scutellaria baicalensis - Pueraria Mirifica drug on the treatment of NAFLD.

KEYWORDS

Non-alcoholic fatty liver disease; Scutellaria baicalensis; Pueraria lobata; network pharmacology

CITE THIS PAPER

Zhou Changjing, Lu Bo, Exploration on the Mechanism of Action of Huangqin and Gegen in the Treatment of Non-Alcoholic Fatty Liver Disease Based on Network Pharmacology. MEDS Basic Medicine (2024) Vol. 2: 65-71. DOI: http://dx.doi.org/10.23977/medbm.2024.020109.

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