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Cadmium Exposure and Health Effects

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DOI: 10.23977/afshn.2024.060103 | Downloads: 25 | Views: 341


Xinru Lin 1, Ming Gong 1


1 College of Food Science and Engineering, Shandong Agricultural University, Taian, 271018, China

Corresponding Author

Xinru Lin


This article provides a comprehensive review of the sources, exposure pathways, biological effects, and toxicology of cadmium, as well as the diagnostic methods for cadmium poisoning. We delve into the release of cadmium from natural and anthropogenic sources, occupational and environmental exposure pathways, and its impact on human health, including its absorption, distribution, metabolism, and excretion processes. Additionally, the article covers specific health issues caused by cadmium, such as kidney damage and osteoporosis, along with current biomarkers used for diagnosing cadmium poisoning. By synthesizing current research findings, our aim is to offer strategies and insights for the prevention, diagnosis, and treatment of cadmium poisoning.


Cadmium, Cadmium Exposure, Cadmium Damage


Xinru Lin, Ming Gong, Cadmium Exposure and Health Effects. Advances in Food Science and Human Nutrition (2024) Vol.6: 15-20. DOI:


[1] Su, Y., et al., Rescue effects of Se-enriched rice on physiological and biochemical characteristics in cadmium poisoning mice. Environmental Science and Pollution Research, 2021. 28(16): p. 20023-20033.
[2] Zhou, Y.-s., et al., Treatment of An Acute Severe Cadmium Poisoning Patient Combined with Multiple Organ Dysfunction Syndromes by Integrated Chinese and Western Medicines: A Case Report. Chinese Journal of Integrative Medicine, 2020. 26(11): p. 853-856.
[3] Fowler, B.A., Monitoring of human populations for early markers of cadmium toxicity: a review. Toxicol Appl Pharmacol, 2009. 238(3): p. 294-300.
[4] Qing, Y., et al., Dose–response evaluation of urinary cadmium and kidney injury biomarkers in Chinese residents and dietary limit standards. Environmental Health, 2021. 20(1).
[5] Balali-Mood, M., et al., Toxic Mechanisms of Five Heavy Metals: Mercury, Lead, Chromium, Cadmium, and Arsenic. Front Pharmacol, 2021. 12: p. 643972.
[6] Charkiewicz, A.E., et al., Concentration of Selected Elements and Antioxidative Potential in a Group of Males Working in the Metal Industry: Elements And Antioxidative Potential In Men. Am J Mens Health, 2019. 13(3): p. 1557988319851954.
[7] Ganguly, K., et al., Cadmium in tobacco smokers: a neglected link to lung disease? Eur Respir Rev, 2018. 27(147).
[8] Bohlandt, A., et al., High concentrations of cadmium, cerium and lanthanum in indoor air due to environmental tobacco smoke. Sci Total Environ, 2012. 414: p. 38-41.
[9] Hogervorst, J., et al., House dust as possible route of environmental exposure to cadmium and lead in the adult general population. Environ Res, 2007. 103(1): p. 3-7.
[10] Schaefer, H.R., S. Dennis, and S. Fitzpatrick, Cadmium: Mitigation strategies to reduce dietary exposure. J Food Sci, 2020. 85(2): p. 260-267.
[11] Ruczaj, A. and M.M. Brzoska, Environmental exposure of the general population to cadmium as a risk factor of the damage to the nervous system: A critical review of current data. J Appl Toxicol, 2023. 43(1): p. 66-88.
[12] Jarup, L., Hazards of heavy metal contamination. Br Med Bull, 2003. 68: p. 67-82.
[13] Jarup, L. and A. Akesson, Current status of cadmium as an environmental health problem. Toxicol Appl Pharmacol, 2009. 238(3): p. 1-8.
[14] Tchounwou, P.B., et al., Heavy metal toxicity and the environment. Exp Suppl, 2012. 101: p. 33-44.
[15] Paschal, D.C., et al., Exposure of the U.S. population aged 6 years and older to cadmium: 1988-1994. Arch Environ Contam Toxicol, 2000. 38(3): p. 77-83.
[16] Jean, J., et al., Dietary exposure to cadmium and health risk assessment in children - Results of the French infant total diet study. Food Chem Toxicol, 2018. 115: p. 358-364.
[17] Satarug, S., Dietary Cadmium Intake and Its Effects on Kidneys. Toxics, 2018. 6(1).
[18] Clemens, S., Toxic metal accumulation, responses to exposure and mechanisms of tolerance in plants. Biochimie, 2006. 88(11): p. 17-19.
[19] Franz, E., et al., A chain modeling approach to estimate the impact of soil cadmium pollution on human dietary exposure. J Food Prot, 2008. 71(12): p. 4-10.
[20] Yang, J., et al., Heavy metal contamination in soils and vegetables and health risk assessment of inhabitants in Daye, China. Journal of International Medical Research, 2018. 46(8): p. 3374-3387.
[21] Yang, Q., et al., A review of soil heavy metal pollution from industrial and agricultural regions in China: Pollution and risk assessment. Sci Total Environ, 2018. 642: p. 690-700.
[22] Cai, K., et al., Pollution and Health Risk Assessment of Carcinogenic Elements As, Cd, and Cr in Multiple Media—A Case of a Sustainable Farming Area in China. Sustainability, 2019. 11(19).
[23] Cheng, Z., et al., Characteristics and health risk assessment of heavy metals exposure via household dust from urban area in Chengdu, China. Science of The Total Environment, 2018. 619-620: p. 621-629.
[24] Godt, J., et al., The toxicity of cadmium and resulting hazards for human health. J Occup Med Toxicol, 2006. 1: p. 22.
[25] Charkiewicz, A.E., et al., Cadmium Toxicity and Health Effects-A Brief Summary. Molecules, 2023. 28(18).
[26] Wang, M., et al., A review on Cadmium Exposure in the Population and Intervention Strategies Against Cadmium Toxicity. Bull Environ Contam Toxicol, 2021. 106(1): p. 65-74.
[27] Genchi, G., et al., The Effects of Cadmium Toxicity. Int J Environ Res Public Health, 2020. 17(11).
[28] Lech, T. and J.K. Sadlik, Cadmium Concentration in Human Autopsy Tissues. Biol Trace Elem Res, 2017. 179(2): p. 172-177.
[29] Nordberg, M. and G.F. Nordberg, Metallothionein and Cadmium Toxicology-Historical Review and Commentary. Biomolecules, 2022. 12(3).
[30] Rafati Rahimzadeh, M., et al., Cadmium toxicity and treatment: An update. Caspian J Intern Med, 2017. 8(3): p. 135-145.
[31] Joseph, P., Mechanisms of cadmium carcinogenesis. Toxicol Appl Pharmacol, 2009. 238(3): p. 2-9.
[32] Filipic, M., Mechanisms of cadmium induced genomic instability. Mutat Res, 2012. 733(1-2): p. 69-77.
[33] Djurasevic, S., et al., The Protective Effects of Probiotic Bacteria on Cadmium Toxicity in Rats. J Med Food, 2017. 20(2): p. 189-196.
[34] Huang, Y., et al., Toxicity of cadmium and its health risks from leafy vegetable consumption. Food Funct, 2017. 8(4): p. 1373-1378.
[35] Jin YY, Zhou R, Kuang XY (2018) Research progress on renal injury induced by cadmium. J Environ Occup Med 35:180–184
[36] Li, Y.E., et al., Liver changes induced by cadmium poisoning distinguished by confocal Raman imaging. Spectrochimica Acta Part a-Molecular and Biomolecular Spectroscopy, 2020. 225.
[37] Järup L et al (2000) Low level exposure to cadmium and early kidney damage: the OSCAR study. Occup Environ Med 57:668–672
[38] Li, H., et al., Smoking-induced risk of future cardiovascular disease is partly mediated by cadmium in tobacco: Malmö Diet and C
ancer Cohort Study. Environ Health, 2019. 18(1): p. 56.
[39] Elez, D., J. Dundjerski, and G. Matić, Cadmium affects the redox state of rat liver glucocorticoid receptor. Cell Biol Toxicol, 2001. 17(3): p. 69-77.
[40] Zalups, R.K. and S. Ahmad, Molecular handling of cadmium in transporting epithelia. Toxicol Appl Pharmacol, 2003. 186(3): p. 63-68.
[41] Omeljaniuk, W.J., et al., Cadmium and Lead in Women Who Miscarried. Clin Lab, 2018. 64(1): p. 59-67.
[42] Charkiewicz, Angelika E., et al., Changes in Dietary Patterns and the Nutritional Status in Men in the Metallurgical Industry in Poland Over A 21-Year Period. Annals of Nutrition and Metabolism, 2018. 72(2): p. 161-171.
[43] Thompson, J. and J. Bannigan, Cadmium: toxic effects on the reproductive system and the embryo. Reprod Toxicol, 2008. 25(3): p. 4-15.
[44] Pizent, A., B. Tariba, and T. Živković, Reproductive toxicity of metals in men. Arh Hig Rada Toksikol, 2012. 63 Suppl 1: p. 35-46.
[45] Chandel, M. and G. Jain, Toxic effects of transition metals on male reproductive system: A review. Journal of Environmental and Occupational Science, 2014. 3(4).
[46] Fagerberg, B., et al., Cadmium exposure is accompanied by increased prevalence and future growth of atherosclerotic plaques in 64-year-old women. J Intern Med, 2012. 272(6): p. 1-10.
[47] Everett, C.J. and I.L. Frithsen, Association of urinary cadmium and myocardial infarction. Environ Res, 2008. 106(2): p. 4-6.
[48] Wuana, R.A. and F.E. Okieimen, Heavy Metals in Contaminated Soils: A Review of Sources, Chemistry, Risks and Best Available Strategies for Remediation. ISRN Ecology, 2011. 2011: p. 1-2.
[49] Nejabat, M., et al., Health risk assessment of heavy metals via dietary intake of wheat in Golestan Province, Iran. Human and Ecological Risk Assessment: An International Journal, 2017. 23(5): p. 1193-1201.
[50] Silver, M.K., B. Lozoff, and J.D. Meeker, Blood cadmium is elevated in iron deficient U.S. children: a cross-sectional study. Environmental Health, 2013. 12(1): p. 117.
[51] Chen, S., et al., Association of blood cadmium with all-cause and cause-specific mortality in patients with hypertension. Front Public Health, 2023. 11: p. 1106732.
[52] Chen, X.Y., et al., Urine metabolomic characteristics of female patients with occupational chronic cadmium poisoning after 15 years of treatment. Biomedical Chromatography, 2023. 37(1).

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