Author(s)

Qian Wang ^1,2, Xuezhong Li ³, Wenjing Huang ⁴

Affiliation(s)

¹ Division of Nephrology, Affiliated Hospital of Hebei University, Baoding, 071000, China
² Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province, No. 212 of Yuhua East Road, Lianchi District, Baoding, 071000, China
³ Intensive Care Unit, Affiliated Hospital of Hebei University, Baoding, 071000, China
⁴ Ultrasound Diagnosis Department, Affiliated Hospital of Hebei University, Baoding, 071000, China

Corresponding Author

Xuezhong Li

ABSTRACT

This paper aims to explore the effect of lanthanum carbonate on vascular calcification and its related molecular mechanism. In order to deeply understand its mechanism of action, this paper adopts animal model and molecular biology experimental methods to carry out systematic research. In terms of methods, this paper established an animal model of vascular calcification, and compared the pathological changes and biochemical indexes between the experimental group and the control group, which confirmed the induction effect of lanthanum carbonate on vascular calcification. Furthermore, the expression level of vascular calcification-related genes was detected by fluorescence quantitative PCR, which revealed the significant regulatory effect of lanthanum carbonate on these genes. In addition, the molecular mechanism of lanthanum carbonate's regulation of gene expression was discussed by bioinformatics and molecular biology. The results show that lanthanum carbonate can effectively regulate the expression of vascular calcification-related genes, which is achieved by binding to gene promoter region and influencing signal pathway and transcription factor activity. These findings not only help us to deeply understand the pathogenesis of vascular calcification, but also provide a useful reference for the potential application of lanthanum carbonate in the treatment of related diseases.

KEYWORDS

Lanthanum carbonate; Vascular calcification; Calcium and phosphorus metabolism

CITE THIS PAPER

Qian Wang, Xuezhong Li, Wenjing Huang, Regulation of Gene Expression Related to Vascular Calcification by Lanthanum Carbonate. MEDS Basic Medicine (2024) Vol. 2: 114-120. DOI: http://dx.doi.org/10.23977/medbm.2024.020115.

REFERENCES

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