Author(s)

Sihan Liu ¹

Affiliation(s)

¹ Beijing JT International Education, Beijing, China

Corresponding Author

Sihan Liu

ABSTRACT

This paper studies the association of neurotransmitter changes with behavioral manifestations on a mouse model for Parkinson's disease. The experimental results showed mice in the Parkinson's disease model group had significantly reduced dopamine content and decreased motor functions. Dopamine content correlated positively with total moving distance and rotarod holding time. These results suggest a direct link between decline in motor function and damage to dopaminergic neurons. The results carry out the close relationship between damage in dopaminergic neurons and movement disorder during Parkinson's disease and offer essential experimental bases for the treatment of the same disease. The present research will, hence, be of theoretical value in the basis for Parkinson's disease studies by revealing the close relationship between neurotransmitter changes and motor dysfunction in Parkinson's disease and indicating directions to follow in further investigations.

KEYWORDS

Parkinson's disease, dopamine, mouse model, behavioral tests, neurotransmitters

CITE THIS PAPER

Sihan Liu, Neurotransmitter changes and behavioral manifestations in mouse models of Parkinson's disease. MEDS Basic Medicine (2024) Vol. 2: 20-26. DOI: http://dx.doi.org/10.23977/medbm.2024.020204.

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