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  4. Vol 2, Issue 2, 2024

Mechanisms of Action of Imperata Cylindrica Root Extract on Azithromycin-Induced Nephropathy in Rats

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DOI: 10.23977/medbm.2024.020205 | Downloads: 9 | Views: 256

Author(s)

Yuming Wei 1

Affiliation(s)

1 Guangxi Health Science College, Nanning, Guangxi, 530023, China

Corresponding Author

Yuming Wei

ABSTRACT

This paper is to investigate the protective effects of Imperata cylindrica root extract on renal function and its potential mechanisms against azithromycin-induced nephropathy in rats. This study involved four groups of male Wistar rats: a control group, an azithromycin-only group, an Imperata cylindrica group, and a combination group treated with both azithromycin and the extract. We measured serum creatinine and blood urea nitrogen (BUN) levels, conducted histological examinations of kidney tissues, and evaluated inflammatory and oxidative stress markers through molecular assays over a 28-day period. Rats treated with Imperata cylindrica and azithromycin showed significantly improved renal function markers compared to those treated with azithromycin alone. Histological analysis indicated less kidney damage, with notable reductions in tubular dilatation and inflammatory cell infiltration. Molecular studies revealed decreased levels of TNF-α and IL-6, and increased activity of antioxidant enzymes SOD and CAT. Imperata cylindrica root extract effectively mitigates renal damage induced by azithromycin, primarily through anti-inflammatory and antioxidant mechanisms. Despite promising findings, the study's limitations include its duration, single-dose regimen, and lack of female subjects. Further studies exploring varied dosages and long-term effects are necessary, along with clinical trials to confirm these effects in humans.

KEYWORDS

Imperata cylindrica root extract; Azithromycin-induced nephropathy; Renal function markers; Anti-inflammatory effects; Antioxidant mechanisms

CITE THIS PAPER

Yuming Wei, Mechanisms of Action of Imperata Cylindrica Root Extract on Azithromycin-Induced Nephropathy in Rats. MEDS Basic Medicine (2024) Vol. 2: 27-33. DOI: http://dx.doi.org/10.23977/medbm.2024.020205.

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