Author(s)

Yinsong Hu ^1,2, Haitao Jiao ³, Jinyan Zhao ¹

Affiliation(s)

¹ College of Basic Medicine, Chengde Medical University, Chengde, Hebei, China
² Bioinformatics Research Lab, Chengde Medical University, Chengde, Hebei, China
³ Clinical Skills Teaching Center, Chengde Medical University, Chengde, Hebei, China

Corresponding Author

ABSTRACT

This study uses bioinformatics methods to analyze the expression and clinical significance of human MMP gene family (MMPs) in lung adenocarcinoma (LUAD). The GSE115002 dataset from the GEO database is downloaded to analyze the expression of MMPs. The chromosomal localization of differentially expressed MMPs is determined. Kaplan-Meier Plotter is used to analyze the relationship between MMPs’ expression and the overall survival (OS) and disease-free survival (DFS) of LUAD patients. As a result, we found that the expression levels of MMP1, MMP3, MMP7, MMP9, MMP10, MMP11, MMP12 and MMP13 show marked elevation in tumor tissues. MMP-11 is located in the q36.3 segment of human chromosome 7, while MMP-9 is situated in the q13.12 segment of human chromosome 20. Other MMPs are primarily localized in the q22.2 region of human chromosome 11. Elevated expression of MMP1, MMP3, MMP7, MMP10, MMP11 and MMP12 is significantly associated with poor prognosis in LUAD patients. To conclude, the expression levels of MMP1, MMP3, MMP7, MMP10, MMP11 and MMP12 are significantly upregulated in LUAD. They are expected to become biomarkers for LUAD prognosis.

KEYWORDS

CITE THIS PAPER

Yinsong Hu, Haitao Jiao, Jinyan Zhao, Bioinformatics Analysis of the Expression and Clinical Significance of MMPs in Lung Adenocarcinoma. MEDS Basic Medicine (2025) Vol. 3: 1-5. DOI: http://dx.doi.org/10.23977/medbm.2025.030101.

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