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  4. Vol 3, Issue 1, 2025

The Value of Vaginoscopic Hysteroscopy in the Early Diagnosis of Endometrial Cancer: A Prospective Randomized Controlled Study

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DOI: 10.23977/medbm.2025.030124 | Downloads: 0 | Views: 63

Author(s)

Xiaohang Zheng 1, Ruxue Bai 1,2, Caixia Liu 1, Xiaoer Shi 1, Yongpai Peng 1,3, Xinru Yang 1

Affiliation(s)

1 Shenshan Medical Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Shanwei, China
2 Guangdong Provincial Key Laboratory of Cancer Pathogenesis and Precision Diagnosis and Treatment, Shanwei, China
3 Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

Corresponding Author

Xinru Yang

ABSTRACT

This study aims to evaluate the application value of transvaginal endoscopy versus conventional hysteroscopy for the early diagnosis of endometrial carcinoma (EC). A total of 193 patients with abnormal uterine bleeding (AUB) who underwent hysteroscopic examination at Sun Yat-sen Memorial Hospital, Shenshan Central Hospital between October 2023 and September 2024 were enrolled and randomly assigned to the experimental group (vaginoscopic hysteroscopy, n=69) or the control group (traditional hysteroscopy, n=124). Using postoperative pathological results as the gold standard, we compared the two groups in terms of diagnostic accuracy, pain scores, patient satisfaction, and operator maneuverability. The concordance rates between hysteroscopic and pathological findings were 97.1% in the experimental group and 97.5% in the control group, with no statistically significant difference (P > 0.05). The pain score was significantly lower in the experimental group than in the control group [2 (IQR: 1.5–2.5) vs. 4 (IQR: 3–5), P < 0.001]. Patient satisfaction was significantly higher in the experimental group than in the control group (59.4% vs. 32.3%, P < 0.001). The examination time was shorter in the experimental group [1.1 minutes (IQR: 0.8–1.3) vs. 1.5 minutes (IQR: 1.1–1.8), P < 0.001], and the operator maneuverability score—defined as the sum of "smooth" and "very smooth" ratings—was higher (63.8% vs. 37.9%, P < 0.05). The complication rates were 1.4% and 1.6%, respectively. Vaginoscopic hysteroscopy demonstrates substantial value in the early diagnosis of endometrial cancer, characterized by simplicity of operation, minimal invasiveness, and good patient tolerance, making it worthy of promotion in outpatient settings.

KEYWORDS

Vaginoscopic hysteroscopy; Hysteroscopy; Endometrial cancer; Early diagnosis; Randomized controlled trial

CITE THIS PAPER

Xiaohang Zheng, Ruxue Bai, Caixia Liu, Xiaoer Shi, Yongpai Peng, Xinru Yang, The Value of Vaginoscopic Hysteroscopy in the Early Diagnosis of Endometrial Cancer: A Prospective Randomized Controlled Study. MEDS Basic Medicine (2025) Vol. 3: 168-177. DOI: http://dx.doi.org/10.23977/medbm.2025.030124.

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